The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans

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The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans.

The Caenorhabditis elegans daf-2/insulin-like signaling pathway is critical for regulating development, longevity, metabolism and stress resistance. We identified the 14-3-3 protein FTT-2 to be a new regulatory component of this pathway. We found that RNAi knock down of ftt-2 specifically enhanced the daf-2-mediated dauer formation phenotype. Furthermore, ftt-2 knock down caused the nuclear acc...

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ژورنال

عنوان ژورنال: Developmental Biology

سال: 2007

ISSN: 0012-1606

DOI: 10.1016/j.ydbio.2006.10.013